- Synthesis of an ovoid chiral cage
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Evidence for the formation of an ovoid chiral cage, resulting from the auto-assembly of two hexafunctional and three tetrafunctional modules reacting through dynamic covalent bond formation, is provided. Georg Thieme Verlag Stuttgart.
- Couty, Fran?ois,David, Olivier R. P.
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scheme or table
p. 1945 - 1948
(2010/04/05)
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- Combinatorial chemistry for ligand development in catalysis: Synthesis and catalysis screening of peptidosulfonamide tweezers on the solid phase
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On the basis of a pyrrolidine tweezer 1, a library of peptidosulfonamide tweezers (15a-e, 16a-e was synthesized on the solid phase. This library was screened in a simultaneous substrate screening procedure for the ability to enantioselectively catalyze the Ti(O-i-Pr)4-mediated addition of diethylzinc to aldehydes. One of the best solid-phase tweezer catalyst (i.e., 16d, giving an ee of 32% in solid-phase catalysis) was resynthesized in solution (compounds 20 and 21). The now homogeneous solution-phase catalysis showed even better enantioselectivity (i.e., up to 66%).
- Brouwer, Arwin J.,van Der Linden, Heiko J.,Liskamp, Rob M. J.
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p. 1750 - 1757
(2007/10/03)
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- Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part
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With preservation of selectivity, the hinge part of tweezerlike synthetic receptor molecules can be varied to achieve a higher affinity. The synthetic peptidosulfonamide receptor (below left; R = Disperse Red 1) with the bis(aminomethyl)benzoic acid hinge selectively bound the tripeptide shown below on the right (K(a) = 4100 M-1). Combination of a diversity in the hinge part with that present in the tweezer arms will provide access to large and diverse synthetic receptor libraries.
- Loewik, Dennis W. P. M.,Weingarten, W. David,Broekema, Matthias,Brouwer, Arwin J.,Still, W. Clark,Liskamp, Rob M. J.
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p. 1846 - 1850
(2007/10/03)
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- Novel quinolone derivatives as potent antibacterials
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Several 7-(3R,4R-N,N'-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3R,4R-N,N'-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-cyclopropyl-4 -oxoquinoline-3-carboxylic acid was found
- Lohray, Braj B.,Baskaran,Srinivasa Rao, Bonthu,Mallesham,Bharath,Yadi Reddy,Venkateswarlu,Sadhukhan, Ashok K.,Kumar, M. Sitaram,Sarnaik, Hemant M.
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p. 525 - 528
(2007/10/03)
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- Sequence-Selective Peptide Binding with a Synthetic Receptor
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A dye-labeled variant of a highly substrate-selective synthetic receptor for peptides is described and its binding selectivity for certain di- and tripeptide sequences is elucidated using an encoded combinatorial library.
- Yoon, Seung Soo,Still, W. Clark
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p. 567 - 578
(2007/10/02)
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