Synthesis and evaluation of novel pyrazolo[1,5-a]pyrimidine derivatives as nonpeptide angiotensin II receptor antagonists
A novel series of 6-alkyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid derivatives was prepared as angiotensin II (AII) receptor antagonists. When evaluated in an in vitro binding assay using COS cells transfected with a cDNA encoding a hu