cas 16200-53-6, 3-NORADAMANTANECARBOXYLIC ACID | Articles data ｜lookchem

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16200-53-6

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Compounds with urotropin structure. XLVII. A new synthesis of 1,2- and 2,6-disubstituted adamantanes
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Stetter,Thomas,Meyer
p. 863 - 867
(1970)
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Discovery of adamantane based highly potent HDAC inhibitors
Herein, we report the development of highly potent HDAC inhibitors for the treatment of cancer. A series of adamantane and nor-adamantane based HDAC inhibitors were designed, synthesized and screened for the inhibitory activity of HDAC. A number of compounds exhibited GI50 of 10-100 nM in human HCT116, NCI-H460 and U251 cancer cells, in vitro. Compound 32 displays efficacy in human tumour animal xenograft model.
Gopalan, Balasubramanian,Ponpandian, Thanasekaran,Kachhadia, Virendra,Bharathimohan, Kuppusamy,Vignesh, Radhakrishnan,Sivasudar, Velaiah,Narayanan, Shridhar,Mandar, Bhonde,Praveen, Rajendran,Saranya, Nithyanandan,Rajagopal, Sriram,Rajagopal, Sridharan
p. 2532 - 2537
(2013/06/27)

HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF FUNGAL INFECTIONS
Described are bridged compounds of the formula (I), their analogs, tautomeric forms, stereoisomers, geometrical isomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The invention relates to compositions and methods to treat fungal infection. These compounds are selective HDAC inhibitors that act as inherent antifungal compounds or enhance the activity of other antifungal compounds such as azoles.
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Page/Page column 28

(2011/06/16)

SYNTHESIS OF 3-NORADAMANTAMINE
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Jawdosiuk, Mikolaj,Kovacic, Peter
p. 53 - 62
(2007/10/02)

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284687-44-1
4-Nitrophenyl noradamantane-1-carboxylate

Chemical Properties

Appearance/Colour :white crystalline powder and chunks or crystals
Melting Point: 104-108 ºC
Boiling Point: 288°C at 760mmHg
Flash Point:133.1°C
Density: 1.291g/cm³
Solubility:almost transparency in Methanol
Vapor Pressure: 0.001mmHg at 25°C
Refractive Index: 1.4859 (estimate)
PKA: 4.78±0.20(Predicted)
PSA: 37.30000
LogP: 1.89730

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