- Design, synthesis, and structure-activity relationships of a new series of α-adrenergic agonists: Spiro[(1,3-diazacyclopent-1-ene)-5,2'-(1',2',3',4'- tetrahydronaphthalene)]
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The contractions induced by a partial α1-adrenoceptor agonist in cutaneous veins, such as the saphenous vein, show a particular sensitivity to changes in local temperature: the contractility to a partial α1- adrenoceptor agonist incr
- Cordi,Lacoste,Descombes,Courchay,Vanhoutte,Laubie,Verbeuren
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p. 4056 - 4069
(2007/10/03)
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- BENZOSPIROALKENE DERIVATIVES
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Compounds of formula (I): STR1 wherein:--X represents--CH 2--,--(CH 2) 2--,--CH=CH--,--O--CH 2--,--S--CH 2--,--SO--CH 2--or--SO 2--CH 2--, --R. sub. 1 represents hydrogen or halogen or linear or branched (C 1-C. sub.6)alkoxy,--R 2 represents l
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