Reactivity of 7-(2-Dimethylaminovinyl)pyrazolopyrimidines: Synthesis of Pyrazolopyridopyrimidine Derivatives as Potential Benzodiazepine Receptor Ligands. 2.
A series of pyrazolopyridopyrimidin-6-ones was obtained by reaction of ammonium acetate with ethyl 7-dimethylaminovinylpyrazolopyrimidine-6-carboxylates and these had been prepared from ethyl 7-methylpyrazolopyrimidine-6-carboxylates by reaction with dimethylformamide dimethylacetat.Under these conditions the compounds bearing a 2-hydroxy group were also O-alkylated.During the preparation of the ethyl 2-hydroxy-7-methyl-3-phenylpyrazolopyrimidine-6-carboxylate the corresponding 5-methyl isomer was isolated and identified.
Bruni, Fabrizio,Selleri, Silvia,Costanzo, Annarella,Guerrini, Gabriella,Casilli, Maria Lucia,Giusti, Laura
p. 291 - 298
(2007/10/02)
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