- Phosphane- and amine-catalyzed ring-opening reactions of cyclopropenones with isatin derivatives: Synthesis of carboxylated 1H-indoles and multisubstituted 2H-pyran-2-ones
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The phosphane- and amine-catalyzed ring-opening reactions of cyclopropenones with isatin derivatives give different reaction outcomes. Under phosphane catalysis, carboxylated 1H-indoles are afforded in good yields, and under amine catalysis, multisubstituted 2H-pyran-2-ones are provided in moderate yields. The mechanistic aspects of these reactions are discussed on the basis of control experiments. Phosphane- and amine-catalyzed ring-opening reactions of cyclopropenones with isatin derivatives are developed. These reactions offer a facile synthetic method to construct carboxylated 1H-indoles and multisubstituted 2H-pyran-2-ones; Boc = tert-butoxycarbonyl, DABCO = 1,4-diazabicyclo[2.2.2]octane. Copyright
- Zhao, Wen-Tao,Tang, Xiang-Ying,Shi, Min
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supporting information
p. 2672 - 2676
(2014/05/06)
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