A 1,2-O-O-SILYL-MIGRATION-CLAISEN-REARRANGEMENT-SN2'-DISPLACEMENT SEQUENCE IN THE STEREOSELECTIVE SYNTHESIS OF 5-OXAPROSTANOID DERIVATIVES
A novel stereocontrolled route to 5-oxaprostaglandin and PGF intermediates is described, which starts from the ene-diols (6/7) and uses a sequence of Claisen rearrangement, 1,2-O-O-silyl migration and SN2'-cyclization reactions (9b10a/b via
Mulzer, Johann,Greifenberg, Stefan
p. 93 - 96
(2007/10/02)
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