- Synthesis of N,N-disubstituted 3-amino-1,4-diynes and 3-amino-1-ynes by addition of alkynyldimethylaluminum reagents to N,N-disubstituted formamides and N,O-acetals
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A wide range of alkynyldimethylaluminum reagents, which were derived from terminal alkynes and trimethylaluminum, underwent a double addition to N,N-disubstituted formamides and their acetals to provide the corresponding N,N-disubstituted 3-amino-1,4-diynes in moderate to excellent yields. Also, these reagents smoothly underwent the addition to N,O-acetals to give the corresponding N,N-disubstituted 3-amino-1-ynes in excellent yields.
- Korbad, Balaji L.,Lee, Sang-Hyeup
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p. 5089 - 5095
(2014/08/18)
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