Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides
The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.
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(2020/01/09)
CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines
A class of oxalic diamides are found to be effective ligands for promoting CuI-catalyzed aryl amination with less reactive (hetero)aryl chlorides. The reaction proceeds at 120 °C with K3PO4 as the base in DMSO to afford a wide range of (hetero)aryl amines in good to excellent yields. The bis(N-aryl) substituted oxalamides are superior ligands to N-aryl-N′-alkyl substituted or bis(N-alkyl) substituted oxalamides. Both the electronic nature and the steric property of the aromatic rings in ligands are important for their efficiency.
SYNTHESIS OF AMINES OF THE TETRAHYDRO-3-FURYL SERIES
From β-tetrachlorotetrahydrofuran a series of aromatic and aliphatic amines has been synthesized, the members of which are of interest as biologically active compounds.It is shown to be possible to convert them to water-soluble salts by sequential treatme
Talipov, R. F.,Sagitdinova, Kh. F.,Gaisin, A. M.,Petrov, D. V.,Safarov, M. G.
p. 272 - 274
(2007/10/02)
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