- Synthesis method of diafenthiuron impurity C
-
The invention provides a preparation method of a diafenthiuron impurity C. According to the preparation method of the diafenthiuron impurity C, 2, 6-isopropylaniline, 4-toluenesulfonyl chloride, phenol, N, N-diisopropylethylamine and the like are used as
- -
-
-
- Facile synthesis of 2,3,5,6-tetrabromo-4-methyl-nitrocyclohexa-2,5-dien-1- one, a mild nitration reagent
-
Nitrocylcohexadienones have been applied as nitration reagents for mild, mono-nitrating reactions. The original synthesis of 2,3,5,6-tetrabromo-4-methyl- 4-nitrocylcohexa-2,5-dien-1-one appeared to be difficult to pursue due to both the solvent system and
- Arnatt, Christopher K.,Zhang, Yan
-
scheme or table
p. 1592 - 1594
(2012/04/10)
-
- Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)- on-3-yl ureas: Potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility
-
4-Aryl-1,8-naphthyridin-2(1H)-on-3-yl urea derivatives with hydrophilic groups were synthesized in order to improve aqueous solubility and pharmacokinetic property. SMP-797 possessing (4-aminophenyl)ureido and 3-(hydroxypropoxyphenyl) moieties showed pote
- Ban, Hitoshi,Muraoka, Masami,Ioriya, Katsuhisa,Ohashi, Naohito
-
-
- Synthesis of SMP-797: A new potent ACAT inhibitor
-
A potent ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor SMP-797 was effectively synthesized by the urea formation of 3-amino-4-aryl-1,8- naphthyridin-2(1H)-one and 4-amino-2,6-diisopropylamine. The synthesis of the former compound involved the Suzuki coupling reaction as a key step, and the latter was prepared by the 4-selective nitration of 2,6-diisopropylaniline using 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone.
- Ban, Hitoshi,Muraoka, Masami,Ohashi, Naohito
-
p. 10081 - 10092
(2007/10/03)
-
- Substituent effects on edge-to-face aromatic interactions
-
Chemical double mutant cycles have been used to measure the magnitude of edge-to-face aromatic interactions in hydrogen-bonded zipper complexes as a function of substituents on both aromatic rings. The interaction energies vary depending on the combinatio
- Carver, Fiona J.,Hunter, Christopher A.,Livingstone, David J.,McCabe, James F.,Seward, Eileen M.
-
p. 2847 - 2859
(2007/10/03)
-