(S,S)-trans-cyclopentane-constrained peptide nucleic acids. A general backbone modification that improves binding affinity and sequence specificity
Replacing the ethylenediamine portion of aminoethylglycine peptide nucleic acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases binding affinity and sequence specificity to complementary DNA, making these modifie
Pokorski, Jonathan K.,Witschi, Mark A.,Purnell, Bethany L.,Appella, Daniel H.
p. 15067 - 15073
(2007/10/03)
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