Mild and efficient H/D exchange of alkanes based on C-H activation catalyzed by rhodium on charcoal
(Chemical Equation Presented) Easy access: In the presence of Rh/C in D2O under H2 at 160°C the H/D exchange reaction of unfunctionalized alkanes can easily occur (see scheme). Inexpensive reagents and mild reaction conditions are used, and fully deuterated products can be obtained after a simple work up procedure.
C-H bond activation by water on a palladium or platinum metal surface
A water molecule is partially cleaved on a palladium or platinum metal surface under hydrothermal conditions to form an active platinum species. The species is effective for C-H bond functionalization which can be applied for H/D-exchange reactions, C-C bond-forming reactions, and C-N bond-forming reactions. Georg Thieme Verlag Stuttgart.
Palladium-catalyzed H-D exchange reaction under hydrothermal condition
Alkenes and alkanes were converted into fully deuterium labelled ones by treatment with palladium on charcoal and deuterium oxide under hydrothermal condition. The simple method to get fully deuterium labelled compounds is easy to apply to various types of organic compounds.