- Ultrasound-Mediated Synthesis of Novel 1,2,3-Triazole-Based Pyrazole and Pyrimidine Derivatives as Antimicrobial Agents
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In the development of novel antimicrobial agents, we synthesized novel 1,2,3-triazole-based pyrazole and pyrimidine derivatives 6(a–f) and 7(a–f) by ultrasound-assisted method. The synthesized compounds were characterized by IR, 1H NMR, 13
- Dofe, Vidya S.,Sarkate, Aniket P.,Shaikh, Zarina M.,Gill, Charansingh H.
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- Synthesis, antimicrobial activity and anti-biofilm activity of novel tetrazole derivatives
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In the development of antimicrobial agents, we designed and synthesized novel tetrazole derivatives. The structures of compounds 6a-f and 7a-f were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis. These compounds were tested for their antimicrobial activity against a series of strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa and for antifungal activity against the strains Candida albicans, Candida glabrata, and Candida tropicalis. Compounds 6e, 6f, 7a, and 7f exhibit potent antimicrobial activities compared to the reference drugs streptomycin and miconazole. Tetrazole derivatives 7a-f also inhibit biofilm formation and compound 7f exhibits best anti-biofilm activity with a biofilm inhibitory concentration (BIC) as low as 0.9 μm.
- Dofe, Vidya S.,Sarkate, Aniket P.,Kathwate, Santosh H.,Gill, Charansingh H.
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p. 325 - 330
(2017/08/18)
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- An improved procedure for the synthesis of 1,5-benzothiazepines using ceric ammonium nitrate (CAN)
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A mild and efficient procedure for the synthesis of various 1,5-benzothiazepines were developed. This method provides an easy access for preparation of 1,5-benzothiazepine derivatives in the presence of 10 mol% catalyst of CAN under ultrasonic irradiation. This method provided clean conversion, mild reaction condition, no use of toxic solvent and shorter reaction time compared to other reported method. Copyright
- Chate, Asha V.,Joshi, Ratnadeep S.,Mandhane, Priyanka G.,Gill, Charansingh H.
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p. 776 - 780
(2012/01/03)
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