COMPOUNDS USEFUL IN INHIBITING DIACYLGLYCEROL O-ACYLTRANSFERASE AND METHODS OF MAKING AND USING THE SAME
Described herein are compounds that may act as an inhibitor of diacylglycerol O- acyltransferase 2 (DGAT2) and/or that may be useful in the treatment of diseases and/or disorders associated with DGAT2. Compositions including such compounds are also described herein along with methods of preparation and use of such compounds and/or compositions.
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Page/Page column 29; 30
(2021/08/20)
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate
Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. We previously developed several classes of 2-aminoquinoline-based nNOS inhibitor
Cinelli, Maris A.,Reidl, Cory T.,Li, Huiying,Chreifi, Georges,Poulos, Thomas L.,Silverman, Richard B.
p. 4528 - 4554
(2020/05/05)
A Concise Enantioselective Synthesis of (+)-L-733,060 and (+)-T-2328 via Sequential Proline Catalysis
A new, sequential proline-catalyzed approach to the synthesis of (+)-L-733,060 and (+)-T-2328 in high optical purity (93% ee) is described starting from phenyl N-Boc imine. The strategy involves proline-catalyzed Mannich reaction of an arylimine with acet
Lalwani, Komal G.,Sudalai, Arumugam
supporting information
p. 1339 - 1343
(2016/06/01)
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