A 5-hydroxy pyrimidine-2-carboxylic acid synthesizing method
The invention discloses a synthesis method for 5-hydroxyl pyrimidine-2-carboxylic acid. The synthesis method comprises the following steps: reacting 5-bromo-2-cyanopyrimidine with phenylcarbinol to generate 5-benzyloxy-2-cyanopyrimidine; then reacting5-benzyloxy-2-cyanopyrimidine in an alkaline condition, dissolving out the product by carrying out an acid adjustment on the reaction solution, and filtering and drying the dissolved solid to obtain the target compound, namely 5-hydroxyl pyrimidine-2-carboxylic acid. The synthesis method disclosed by the invention has the beneficial effects that a synthesis route for 5-hydroxyl pyrimidine-2-carboxylic acid is designed and a preparation method for the compound is provided.
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Paragraph 0023; 024; 0025; 0026
(2016/10/07)
SYNTHESIS AND LIQUID CRYSTAL PROPERTIES OF SUBSTITUTED 5-(ARYLCARBONYLOXY)-2-(p-CYANOPHENYL)PYRIMIDINES
Liquid crystal p-substituted benzoates, biphenylcarboxylates, and benzoyloxybenzoates were obtained on the basis of 5-hydroxy-2-(p-cyanophenyl)pyrimidine.The development of nematogenicity by the esters due to the p-cyanophenyl grouping was noted, and the appearance of the smectic mesophase by the variation of the ring framework of the acid fragment of the molecule was investigated.
Mikhaleva, M. A.,Igonina, G. A.,Savel'ev, V. A.
p. 320 - 325
(2007/10/03)
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