- RuO4-mediated oxidation of tertiary amines. stereoelectronic effects
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Tertiary amines like PhCH2-NMe-CH2R (R = H, Me, CN) underwent RuO4-mediated oxidation by attack at all three N-α-positions. The various reaction products were classified in three groups, according to the functionalized sit
- Petride, Horia,Florea, Cristina,H?rtopeanu, Anca,Stavarache, Cristina
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- RuO4-Mediated oxidation of tertiary amines. Stereoelectronic effects
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Tertiary amines like PhCH2-NMe-CH2R (R = H, Me, CN) underwent RuO4-mediated oxidation by attack at all three N-α-positions. The various reaction products were classified in three groups, according to the functionalized sit
- Florea, Cristina,H?rtopeanu, Anca,Petride, Horia,Stavarache, Cristina
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- Copper-Catalyzed three- Five- or seven-Component coupling reactions: The selective synthesis of cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines based on a strecker-type synthesis
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We have demonstrated that a cooperative catalytic system comprised of CuCl and Cu(OTf)2 could be used to effectively catalyse the three-, five- and seven-component coupling reactions of aliphatic or aromatic amines, formaldehyde, and trimethylsilyl cyanide (TMSCN), and selectively produce in good yields the corresponding cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines.
- Sakai, Norio,Takahashi, Nobuaki,Inoda, Daiki,Ikeda, Reiko,Konakahara, Takeo
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p. 12488 - 12499
(2013/11/06)
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- Facile and selective synthesis of propargylic amines and 1,6-diynes: One-pot three-component coupling reactions of alkynylsilanes, aldehydes and amines by a cooperative catalytic system comprised of CuCl and Cu(OTF) 2
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Described herein is a three-component coupling reaction of alkynylsilanes, aldehydes and amines by a cooperative catalytic system comprised of CuCl and Cu(OTf)2, leading to the production of a variety of propargyl amine derivatives. This catalytic system was successfully applied to the practical preparation of 1,6-diyne derivatives via twice-performed, domino-type coupling reactions.
- Sakai, Norio,Uchida, Naoki,Konakahara, Takeo
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scheme or table
p. 1515 - 1519
(2009/04/07)
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