- Simple and effective method for the synthesis of 3′,5′-substituted 1-β-D-arabinofuranosyluracil
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3′,5′-Substituted arabinofuranosyluracil is a starting compound in 2′-modifications. A convenient and effective method is proposed for the synthesis of 1-(3′,5′-di-o-trityl-β-D-arabinofuranosyl)uracil by successive reactions of 2,2′-cyclization of uridine, 3′,5′-tritylation of the 2,2′-anhydrouridine, and hydrolytic cleavage of the 2,2′-anhydro bond. 1997 Plenum Publishing Corporation.
- Zablotskaya,Segal,Pedersen
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- SYNTHESIS OF 2'-CHLORO-2',3'-DIDEOXY-2',3'-DIDEHYDRO NUCLEOSIDES
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Treatment of O2,2'-anhydrouridine with triphenylmethyl chloride in pyridine at 80 deg C gives mainly the 2'-chlorinated nucleoside 3.Reaction of 2'-chloro-3'-O-trifluoromethanesulfonyl-5'-O-trityl-2'-deoxyuridine (4) with NaOH led exclusively t
- Aerschot, A. Van,Herdewijn, P.
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p. 931 - 936
(2007/10/02)
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