- PYRAZOLO[3,4-D]PYRIMIDIN DERIVATIVE AND ITS USE FOR THE TREATMENT OF LEISHMANIASIS
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The compound 3,3,3-trifluoro-N-((1,4-trans)-4-((3-((S)-2-methylmorpholino)-1H- pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamidehaving the Formula (I) or a salt thereof, its opposite enantiomer, compositions comprising the compound and its use in the treatment or prevention of leishmaniasis, particularly visceral leishmaniasis.
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Page/Page column 37
(2016/08/17)
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- CHROMENONE COMPOUNDS AS PI 3 -KINASE INHIBITORS FOR THE TREATMENT OF CANCER
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The invention concerns chromenone compounds of Formula I; or pharmaceutically-acceptable salts thereof, wherein each of R1, R2, R3, R4, R5, n and R6 has any of the meanings defined hereinbe
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- CHROMENONE DERIVATIVES
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The invention concerns chromenone compounds of Formula I; or pharmaceutically-acceptable salts thereof, wherein each of R1, R2, R3, R4, R5, n and R6 has any of the meanings defined hereinbe
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- THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS
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This invention relates to the use of thiazolopyrimidinone derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3' OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ
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Page/Page column 47
(2010/12/18)
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- COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS
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The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activit
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Page/Page column 116-117
(2009/09/05)
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- COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS
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The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-fu
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Page/Page column 33-34
(2008/06/13)
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- Compounds and compositions as inhibitors of receptor tyrosine kinase activity
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The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, and/or PFGFRα kinase
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Page/Page column 16-18
(2010/02/11)
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- Quinolinecarboxylic acid derivatives, antibacterial agent containing the same
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Novel quinolinecarboxylic acid derivatives of the formula: STR1 wherein Z is STR2 or STR3 in which R1 is hydrogen atom, a halogen atom, hydroxy or a lower alkyloxy; R2 is a halogen atom, hydroxy or a lower alkyloxy; R3 is a lower alkyl; and R4 is hydroxy or a di(lower alkyl)amino, and a pharmaceutically acceptable salt thereof, which have excellent antibacterial activities and are useful as an antibacterial agent, a pharmaceutical composition containing the same, and process for preparing the same.
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