- Antimicrobial 2-pyridones, their compositions and uses
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Compounds having the general structure: are effective antimicrobial agents.
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- Syntheses of ortho-hydroxymethylpyridinols and dioxaphosphorino[m,n-x]pyridines
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Dioxaphosphorino[m,n-x]pyridines compounds have been prepared by condensation of methyl dichlorophosphate with new ortho-hydroxymethylpyridinols.
- Leroy,Despres,Bigan,Blondeau
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p. 2257 - 2272
(2007/10/03)
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- Site-Selectivity in the Reaction of 3-Substituted Pyridine 1-Oxides with Phosphoryl Chloride
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Site-selectivity in the reaction of 3-substituted pyridine 1-oxide with phosphoryl chloride was investigated.When a strongly electron-withdrawing group (e.g.CN, CONRR', COOR, or NO2) was substituted at the 3-position, the reaction of 3-substituted pyridine 1-oxides with phosphoryl chloride yielded 3-substituted 2-chloropyridines as the main products.Keywords- site-selectivity; 3-substituted pyridine 1-oxide; phosphoryl chloride; 3-substituted 2-chloropyridine; chlorination
- Yamanaka, Hiroshi,Araki, Tomio,Sakamoto, Takao
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p. 2244 - 2247
(2007/10/02)
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- Directed Lithiation of 4-Halopyridines: Chemoselectivity, Regioselectivity and Application to Synthesis
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4-Chloro and 4-fluoropyridines were ortho-lithiated by n-butyllithium-TMEDA chelate or lithium diisopropylamide at low temperature.The resulting 3-lithio 4-halopyridines were reacted with electrophiles which led to various 3,4-disubstituted pyridines.The versatility of this functionalization is enhanced by the 4-halogen reactivity towards nucleophiles such as water, methylate and amines.Some of the 3,4-disubstituted synthons were annelated to naphthyridine, xanthone and coumarin or condensed to Hantzsch-ester or to "chlotrimazol" analogues.Lithiation of 4-fluoropyridine led in one step to 3,4-pyridyne, which was trapped by cycloaddition with furans.
- Marsais, F.,Trecourt, F.,Breant, P.,Queguiner, G.
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