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169760-16-1

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Fused heterotricyclic compounds as inhibitors of 17beta-hydroxysteroid dehydrogenase 3
Fused heterotricyclic compounds, methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions containing such compounds.
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Page/Page column 47

(2008/06/13)

Novel compounds and their use as positive AMPA receptor modulators
The invention provides novel compounds represented by the general formula 5 compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.
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(2008/06/13)

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Chemical Properties

Melting Point: 300 °C
Density: 1.23g/cm³
Storage Temp.:2-8°C
Refractive Index: 1.553
PKA: 8.46±0.53(Predicted)
PSA: 69.56000
LogP: -0.60220

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