- New synthesis of estradiol from androsta-1,4-diene-3,17-dione
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A new method for the aromatization of ring A in androsta-1,4-diene-3,17-dione, available from sterols by means of the microbiological degradation of the side chain, was developed. The method consists of the reduction of androsta-1,4-diene-3,17-dione to the corresponding dienediol followed by double C,O-deprotonation of ring A, accompanied by expulsion of the 19-methyl group and formation of estradiol in a high yield.
- Vasiljeva,Demin,Kochev,Lapitskaya,Pivnitsky
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- Reduction of steroidal ketones with amine - Boranes
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Complexes of secondary amines with borane, R2NH·BH 3, surpass sodium borohydride as reducing agents for saturated and unsaturated steroidal 3-, 12-, 17-, and 20-ketones as regards chemo- and regioselectivity and mildness of the reaction conditions. In the case of 12-ketones, stereoselectivity is also improved.
- Leontjev,Vasiljeva,Pivnitsky
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p. 703 - 708
(2007/10/03)
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