cas 170033-47-3, (R)-1-N-Boc-2-methylpiperazine | Articles data ｜lookchem

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170033-47-3

Articles about 170033-47-3Total 6 be found

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GLYCINE TRANSPORTER-1 INHIBITORS
The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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Page/Page column 79

(2009/07/17)

2-(AMINO-SUBSTITUTED)-4-ARYL PYRAMIDINES AND RELATED COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES
A heterocyclic inhibitor having the formula (I), with the variables defined herein, which is useful for treating inflammatory and other physiological disorders in which PKC-theta isoform plays a role.
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Page/Page column 134-135

(2008/06/13)

A novel and facile method to synthesize (R)- and (S)-2-methylpiperazine
A concise and efficient synthesis of (R)- and (S)-2-methylpiperazine in only five steps from (D)- and (L)-alanine is described. The key step is reaction of benzylamine with a bifunctional molecule to build a six-membered ring.
Liu, Bo,Xu, Guang-Yu,Yang, Chun-Hao,Wu, Xi-Han,Xie, Yu-Yuan
p. 4111 - 4118
(2007/10/03)

Use of imidazo?1,5-a!quinolones as neuroprotective agents
The imidazo?1,5-a!quinolines (I) are useful in treating neurological diseases/conditions or chronic neurodegenerative diseases/conditions.
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(2008/06/13)

Imidazo[1,5-A]quinolines for treatment of anxiety and sleep disorders
Imidazo[1,5-a]quinolines of formula (I) which are useful pharmaceutical agents for the treatment of anxiety, sleep disorders, panic states, convulsions and muscle disorders. STR1
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(2008/06/13)

Asymmetric Synthesis of 2,6-Methylated Piperazines
The complete series of enantiopure 2,6-methylated piperazines was synthesized utilizing two alternative reactions in the key bond-forming step.The dimethyl enantiomers, (2R,6R)- and (2S,6S)-2,6-dimethylpiperazine (1, 2), were prepared using either a diastereoselective triflate alkylation or a novel intermolecular Mitsunobu reaction to set the required stereochemistry.The monomethyl derivatives, (R)- and (S)-tert-butyl 2-methyl-1-piperazinecarboxylate (3, 4) were also synthesized employing the Mitsunobu cyclization strategy while the trimethyl compounds, (R)- and (S)-2,2,6- trimethylpiperazine (5, 6) were prepared using an enantiospecific triflate alkylation as the principal reaction.These methods represent efficient, general strategies for preparing a variety of 2,6-methylated piperazines for which the absolute stereochemistry can be readily controlled.
Mickelson, John W.,Belonga, Kenneth L.,Jacobsen, Jon E.
p. 4177 - 4183
(2007/10/02)

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Chemical Properties

Melting Point: 34-36 °C
Boiling Point: 268.7 °C at 760 mmHg
Flash Point:116.3 °C
Density: 0.997 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
PKA: 8.49±0.40(Predicted)
PSA: 41.57000
LogP: 1.48190

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