- 2 -trifluoromethyl -4 - amino - quinoline derivative and application thereof
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The invention discloses 2 -trifluoromethyl -4 - amino - quinoline derivatives and application thereof, and comprises a compound represented by the following general formula I. The prepared compound is used for preparing an anti-tumor active drug, has a go
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Paragraph 0092-0096; 0120-0124
(2021/11/10)
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- Investigations into the flexibility of the 3D structure and rigid backbone of quinoline by fluorine addition to enhance its blue emission
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Achieving the desired structures of organic molecules for targeted applications is vital. Folding caused by weak intermolecular forces plays an important part in their 3D structure. Powerful tools which enable us to do this are currently under investigation by researchers across the globe. On this account, quinoline was chosen as a model scaffold because of its rigid 3D structure. Addition of fluorine was found to result in increased flexibility of the structure with a decrease in the number of intermolecular interactions. This resulted in improvement of their photophysics and blue emission. A total of 19 novel fluoroquinoline molecules were synthesised in order to carry out this study. Of these, grown crystals of 10 compounds were successfully achieved and used. In addition, characterisation techniques such as NMR, HRMS, UV-vis and computational techniques were used to explore the 3D structure of these molecules.
- Alapour,Zamisa,Silva,Alves,Omondi,Ramjugernath,Koorbanally
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p. 2316 - 2323
(2018/04/30)
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- Palladium-catalyzed chloroimination of imidoyl chlorides to a triple bond: An intramolecular reaction leading to 4-chloroquinolines
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(Chemical Equation Presented) In this paper, a new type of effective chloroimination was reported. This reaction afforded 4-chloro-2-perfluoroalkyl quinolines from fluorinated imidoyl chlorides in high yields. This is the first achievement of oxidative addition-reductive elimination type C-Cl bond activation by chloropalladation.
- Isobe, Akira,Takagi, Jun,Katagiri, Toshimasa,Uneyama, Kenji
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supporting information; experimental part
p. 2657 - 2659
(2009/05/27)
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- Potential Antimalarials. XVII. Di- and Mono-Mannich Bases of 2(and 4)-phenol
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Di- and mono-Mannich base derivatives of 2(and 4)-phenols have been prepared for comparison with the 7-trifluoromethyl isomers in tests for antimalarial activity.The order of activity in in vitro tests against t
- Barlin, Gordon B.,Nguyen, Trang M. T.,Kotecka, Barbara,Rieckmann, Karl H.
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- Pesticides
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Compound of the formula (I) are disclosed or a salt thereof, wherein Ar is an optionally substituted polycyclic ring system containing n rings, where n is the integer 2 or 3, at least n-1 rings being aromatic and containing one to three ring nitrogen atoms and optionally containing one or more additional heteroatoms; Q is an alkyl chain containing 1 to 12 carbon atoms and optionally containing a sulphur or one or two oxygen atoms; Q1 is a group (C(R2)=C(R3))a --(C(R4)=C(R5)) wherein a is 0 or 1, R2, R3, R4 and R5 are the same or different, at least two being hydrogen and the other two being independently selected from hydrogen, halo, C1-4 haloalkyl; X is oxygen or sulphur; and R1 is selected from hydrogen and C1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifluoromethyl, trifluoromethylthio or C1-6 alkoxy are described which have activity particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (1), their use in the control of pests and method for their preparation are also disclosed.
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