The first enantioselective synthesis of C3 fluoro-MEP is herein reported. The synthetic pathway developed takes advantage of a selective hydrofluorination of a 2,3-epoxy-1-alcohol to introduce the required tertiary fluoride unit. The Royal Soci
Ghilagaber, Stephanos,Hunter, William N.,Marquez, Rodolfo
p. 97 - 102
(2008/03/14)
Efficient synthesis of the 6,6-spiroacetal of spirofungin A
The 6,6-spiroacetal segment of spirofungin A, an antifungal antibiotic isolated from Streptomyces violaceusniger Tü 4113, was efficiently prepared via the coupling reaction of the Weinreb amide and the alkyne which are readily available from the common in