- Imidazo- and triazolothiadiazines
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Novel imidazo- and triazolothiadiazines of the general formula I STR1 in which R1 =C1 -C4 -alkyl, R2 =H or C1 -C3 -alkyl and the structural element --A--B--=--CH2 --CH2 --, --CH CH--, --CH=N--, --CH2 --CO-- or --CO--CH2 --, and the physiologically aceptable acid-addition salts thereof, are prepared by reacting 2-halo-1-phenylalkanones of the formula II STR2 (meaning of R1 and R2 as in formula I, X=halogen) with compounds of the formula III STR3 (meaning of --A--B-- as in formula I) and, if appropriate, converting the compounds of the formula I formed into the physiologically acceptable acid-addition salts thereof by means of suitable acids. The compounds of the formula I and the physiologically acceptable acid-addition salts thereof are principally suitable for the prevention and treatment of inflammatory--in particular inflammatory rheumatic--disorders. Some of the intermediates formed during the preparation of the compounds of the formula I are also novel, namely 1-amino-2-mercaptoimidazole STR4 and 1-amino-2-thioxo-5-imidazolidinone STR5
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- Substituted 3-phenyl-7H-thiazol[3,2-b][1,2,4]-triazin-7-ones
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Novel substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]-triazin-7-ones of the formula I are disclosed STR1 in which R1, R2 and R3 have the meaning recited in the specification. The compounds are suitable for prevention and treatment of inflammatory disorders.
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