- Antibacterial activity of a new class of tris homoleptic Ru (II)-complexes with alkyl-tetrazoles as diimine-type ligands
-
Herein, we describe a new family of tris chelate homoleptic Ru (II) complexes, [Ru(N^N)3]2+, where the role of the diimine-type ligands (N^N) was fulfilled by 2-pyridyl (PTZ) or 2-quinolyl tetrazole (QTZ) derivatives decorated with various alkyl substituents at the N-2 position of the tetrazole ring. The new Ru (II) complexes with general formula [Ru (PTZ-R)3]2+ and [Ru (QTZ-R)3]2+, were obtained as mixtures of facial (fac) and meridional (mer) isomers, as suggested by NMR (1H, 13C) experiments, and confirmed in the case of mer-[Ru (QTZ-Me)3]2+, by X-ray crystallography. The photophysical behavior of the tetrazole-based [Ru(N^N)3]2+ type species was investigated by UV–vis absorption spectroscopy, providing trends typical of polypyridyl Ru (II) complexes. The new homoleptic complexes fac/mer-[Ru (PTZ-R)3]2+ and fac/mer-[Ru (QTZ-R)3]2+ have been assessed for any eventual antimicrobial activity towards two different bacteria such as Gram-negative Escherichia coli and Gram-positive Deinococcus radiodurans. Whereas being inactive toward E. coli, the response of agar disks diffusion tests suggested that some of the new fac/mer Ru (II) complexes could inhibit the growth of D. radiodurans. This effect was further investigated by determining the growth kinetics in liquid medium of D. radiodurans exposed to the fac/mer-[Ru (PTZ-R)3]2+ and fac/mer-[Ru (QTZ-R)3]2+ complexes at different concentrations. The outcome of these experiments highlighted that the turn-on of the growth inhibitory effect took place as the linear hexyl chain was appended to the PTZ or QTZ scaffold, suggesting also how the inhibitory activity appeared more pronouncedly exerted by the facial isomers fac-[Ru (PTZ-Hex)3]2+ and fac-[Ru (QTZ-Hex)3]2+ (MIC = ca. 3.0 μg/ml) with respect to the corresponding meridional isomers (MIC = ca. 6.0 μg/ml).
- Monti, Nicola,Zacchini, Stefano,Massi, Massimiliano,Hochkoeppler, Alejandro,Giorgini, Loris,Fiorini, Valentina,Stefan, Alessandra,Stagni, Stefano
-
-
Read Online
- Alkyl tetrazoles as diimine (“diim”) ligands for fac-[Re(diim)(CO)3(L)]-type complexes. Synthesis, characterization and preliminary studies of the interaction with bovine serum albumin
-
Herein, we report a new family of luminescent Re(I) complexes with general formula fac-[Re(diim)(CO)3L]0/+ in which the role of the diimine-type chelating ligand (diim) is played by alkylated tetrazoles. In particular, the design of
- Monti, Nicola,Longo, Veronica,Zacchini, Stefano,Vigarani, Giulia,Giorgini, Loris,Bonora, Eugenia,Massi, Massimiliano,Fiorini, Valentina,Stagni, Stefano
-
-
- Thermally Activated Delayed Fluorescence in CuI Complexes Originating from Restricted Molecular Vibrations
-
The mechanism of thermally activated delayed fluorescence (TADF) in molecules in aggregated or condensed solid states has been rarely studied and is not well understood. Nevertheless, many applications of TADF emitters are strongly affected by their lumin
- Li, Guangfu,Nobuyasu, Roberto S.,Zhang, Baohua,Geng, Yun,Yao, Bing,Xie, Zhiyuan,Zhu, Dongxia,Shan, Guogang,Che, Weilong,Yan, Likai,Su, Zhongmin,Dias, Fernando B.,Bryce, Martin R.
-
p. 11761 - 11766
(2017/09/07)
-
- Syntheses of Chelating Tetrazole-Containing Ligands and Studies of Their Palladium(II) and Ruthenium(II) Complexes
-
Eleven chelating tetrazole-containing ligands have been synthesized, and their complexes with palladium(II) and ruthenium(II) prepared.Proton n.m.r. spectroscopy, electronic absorption spectroscopy and cyclic voltammetry have been used to study the nature of the metal-ligand interactions in these complexes.The negatively charged tetrazolate group is shown to be a strong electron donor with very different properties to those of the protonated or alkylated tetrazole group.This leads to pH control of the properties of transition metal complexes containing such ligands.
- Downard, Alison J.,Steel, Peter J.,Steenwijk, Jonathan
-
p. 1625 - 1642
(2007/10/03)
-