The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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Page/Page column 123
(2012/06/16)
Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
The present invention is directed towards new methods of making DE ring intermediates of Formula (III), STR1 wherein Y is H or halogen and R is loweralkyl, which in turn are useful in methods of making camptothecin and camptothecin analogs. The present invention also provides new compounds useful in the methods of making compounds of Formula (III).
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(2008/06/13)
Asymmetric Synthesis of a Key Camptothecin Intermediate from 2-Fluoropyridine
The DE ring camptothecin intermediate II was prepared enantioselectively in six steps from 2-fluoropyridine using a pyridine "halogen-dance" reaction.
Comins, Daniel L.,Saha, Jayanta K.
p. 7995 - 7998
(2007/10/02)
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