- Direct synthesis of anthracenes from o-tolualdehydes and aryl iodides through Pd(II)-Catalyzed sp3 C–H arylation and electrophilic aromatic cyclization
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The first direct synthesis of substituted anthracenes from o-tolualdehydes and aryl iodides via a Pd(II)-catalyzed C–H arylation using an alcohol-bearing transient directing group and subsequent AgOTf-assisted electrophilic aromatic cyclization is described. New transient directing groups consisting of amino acids and amino alcohols enhanced the reactivity, and the C–H arylation was complete in 12 h at 90 °C. By simply changing the silver salt to silver triflate, the one-pot synthesis of anthracene derivatives was carried out using the present reaction conditions.
- Park, Hyojin,Yoo, Kwangho,Jung, Byunghyuck,Kim, Min
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- Controlling the sign and magnitude of screw-sense preference from the C-terminus of an achiral helical foldamer
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The global screw-sense preference of an achiral helical oligomer may be controlled by a single chiral monomer located at one terminus. Remarkably, maximal control is induced in oligomers of the achiral quaternary amino acid Aib by a single C-terminal alaninamide residue, probably because the Ala side chain, though small, is compatible with a 310 helical conformation. The presence or absence of a C-terminal hydrogen bond donor determines the screw sense of the entire oligomer. the Partner Organisations 2014.
- Le Bailly, Bryden A. F.,Clayden, Jonathan
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supporting information
p. 7949 - 7952
(2014/07/08)
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- Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral α-amino amides
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A series of α-amino amides derived from natural amino acids (alanine, valine, phenylalanine, isoleucine, and phenylglycine) have been synthesized and fully characterized. Their Ni(II) complexes prepared from Ni(acac)2 catalyze the enantioselective conjugate addition of diethylzinc to chalcones in high yields and in good enantioselectivities (up to 84%). The side chain of the amino acid and the substituents in the amide nitrogen govern the enantioselectivity of the catalytic process.
- Escorihuela, Jorge,Burguete, M. Isabel,Luis, Santiago V.
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scheme or table
p. 6885 - 6888
(2009/04/07)
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- Method for producing 2-isoquinoline compounds
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1,2,3,4-Tetrahydro-2-isoquinoline-derivatives of the formula STR1 wherein R signifies hydroxy, lower alkylamino, lower alkoxy or phenyl-C2-6 -alkoxy which can carry one or more lower alkyl or lower alkoxy substituents on the phenyl ring, can be
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