- TETRACYCLIC AUTOTAXIN INHIBITORS
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Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
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Paragraph 00392
(2015/06/08)
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- A New Synthesis of Aliphatic Isothiocyanates from Primary Amines, Convenient for In Situ Use
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Primary aliphatic amines react with carbon disulfide in the presence of BOP (benzotriazole-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate) 1, giving the corresponding isothiocyanates in good to high yields and high purity; a number of isothiocyanates are synthesized and isolated or generated in situ and treated with a nucleophile.
- Boas, Ulrik,Jakobsen, Mogens Havsteen
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p. 1995 - 1996
(2007/10/02)
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