A ferrocenyl-DHIPOH/Cu(OAc)2 complex for diastereo- and enantioselective catalysis of the 1,4-addition of glycine derivatives to alkylidene malonates
A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.
Shi, Yu-Hua,Wang, Zheng,Hu, Bin,Wang, Ming,Fossey, John S.,Deng, Wei-Ping
supporting information; experimental part
p. 6010 - 6013
(2012/01/04)
Method for preparation of optically active diarylalanines
A method for preparing a diarylalanine compound is provided. The method includes reacting a diarylaminopropanediol with a reducing agent to form a diarylaminopropanol compound and/or contacting a serine ester derivative with an aryl metal reagent to form diarylaminopropanediol. A diarylmethyloxazolidinone compound is also provided.
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(2008/06/13)
Synthesis of N-BOC-D-Diphenylalanine from L-Serine Methyl Ester Hydrochloride
A convenient six step synthesis of N-BOC-D-diphenylalanine from L-serine methyl ester hydrochloride is described.The preparation of a novel chiral auxiliary, an oxazolidinone derived from D-diphenylalaninol, is also described.
Sibi, Mukund P.,Deshpande, Prasad K.,Loggia, Anthony J. La,Christensen, James W.
p. 8961 - 8964
(2007/10/02)
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