- New supramolecular host systems. 41 Novel diacetal podands, diazacrowns and cryptands
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New and important key podands bearing the cis-1,3,5,7-tetraoxadecalin (TOD) core are reported, viz., 2,6-di(hydroxymethyl)- (2) and 2,6-di(aminomethyl)-cis-l,3,5,7-TOD (6), which lead to the first diazacrown-TOD compounds (9a) and (9b) and a corresponding cryptand (11) in the series. 9a&b exhibit very good alkali and earth-alkali ion inclusion ability with selectivity for K+ and Ba+2. Molecular dynamics (Insight/Discover/AMBER) on the crowns and cryptand were performed, including reparametrized MM3-GE calculations. A convincing case for the TOD based hosts was thus established.
- Frische, Klaus,Greenwald, Moshe,Ashkenasi, Eli,Lemcoff, N. Gabriel,Abramson, Sarah,Golender, Larisa,Fuchs, Benzion
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