- A new and facile tetrachlorosilane-promoted one-pot condensation for the synthesis of a novel series of tetracyclic 1,5-thiazepines
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A new and facile approach for the one-pot synthesis of a novel series of tetracyclic 1,5-thiazepines is described. The reaction occurs through cyclocondensation of fused cyclic ketones, aromatic aldehydes, and 2-aminothiophenol using tetrachlorosilane as
- Khatab, Tamer K.,El-Bayouki, Khairy A.M.,Basyouni, Wahid M.
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- Green, rapid, and highly efficient syntheses of α,α′-bis[(aryl or allyl)idene]cycloalkanones and 2-[(aryl or allyl)idene]-1-indanones as potentially biologic compounds via solvent-free microwave-assisted Claisen–Schmidt condensation catalyzed by MoCl5
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A new, green, and highly efficient protocol for the expeditious preparation of some α,α′-bis[(aryl or allyl)idene]cycloalkanones and 2-[(aryl or allyl)idene]-1-indanones via a simple microwave-assisted Claisen–Schmidt condensation reaction catalyzed by MoCl5 was successfully developed. Outstanding features of the current methodology include the use of solvent-free conditions, simple operation, use of a very inexpensive and available catalyst, low catalyst loading, short reaction times, high yields of the pure products, no harmful by-products, easy workup, and also the applicability of microwave irradiation as a clean source of energy. Furthermore, a gram-scale reaction was successfully conducted, proving the scalability of this current Claisen–Schmidt condensation reaction.
- Bakhshi, Reza,Zeynizadeh, Behzad,Mousavi, Hossein
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p. 623 - 637
(2019/08/26)
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- Michael addition of malononitrile to indenones: Synthesis and characterization of 2-(1-oxo-2,3-dihydro-1H-inden-2-yl) (aryl)(methyl)malononitrile derivatives
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Indanones 3 were prepared from the reaction of indanone (1) with corresponding benzaldehyde derivatives 2, as described in the literature. Then, indenones 3 were subjected to KOtBu-catalyzed Michael addition with malononitrile to give a mixture of diaster
- ?ahin, Betül,Gürdere, Meliha Burcu,Ceylan, Mustafa
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p. 1090 - 1095
(2017/05/25)
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- Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides
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A series of new 4-(3-(4-substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides (7–12) was synthesized starting from 2-(4-substitutedbenzylidene)-2,3-dihydro-1H-inden-1-one (1–6) and 4-hydrazinobenzenesulfonamide. The substituted
- Gul, Halise Inci,Tugrak, Mehtap,Sakagami, Hiroshi,Taslimi, Parham,Gulcin, Ilhami,Supuran, Claudiu T.
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p. 1619 - 1624
(2016/10/09)
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- An efficient synthesis and antimicrobial screening of new hybrid molecules containing coumarin and indenopyridine moiety
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A novel series of hitherto unknown 3-(4-aryl-5H-indeno[1,2-b]pyridin-2-yl)coumarin derivatives 3a-r have been synthesized by the reaction of 3-coumarinyl methyl pyridinium salts 1a-c with appropriate 2-arylidene-1-indanones 2a-f under Krohnke's reaction c
- Brahmbhatt, Dinkar I.,Patel, Chirag V.,Bhila, Varun G.,Patel, Niraj H.,Patel, Apoorva A.
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p. 1596 - 1606
(2015/04/21)
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- Modified Pyridine-Substituted Coumarins: A New Class of Antimicrobial and Antitubercular Agents
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Some new biologically potent coumarin derivatives 7a-f, 8a-f, and 9a-f bearing modified pyridine moieties (indeno[1,2-b]pyridine, 4-azaphenanthrene and benzofuro [3,2-b]pyridine) at the sixth position were designed and synthesized. All the synthesized com
- Giri, Rakesh R.,Lad, Hemali B.,Bhila, Varun G.,Patel, Chirag V.,Brahmbhatt
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p. 363 - 375
(2015/10/29)
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- In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase
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Dual specificity phosphatase 6 (DUSP6) functions as a feedback attenuator of fibroblast growth factor signaling during development. In vitro high throughput chemical screening attempts to discover DUSP6 inhibitors have yielded limited success. However, in
- Korotchenko, Vasiliy N.,Saydmohammed, Manush,Vollmer, Laura L.,Bakan, Ahmet,Sheetz, Kyle,Debiec, Karl T.,Greene, Kristina A.,Agliori, Christine S.,Bahar, Ivet,Day, Billy W.,Vogt, Andreas,Tsang, Michael
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p. 1436 - 1445
(2014/07/21)
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- Evaluation of silica-H2SO4 as an efficient heterogeneous catalyst for the synthesis of chalcones
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We report an efficient silica-H2SO4 mediated synthesis of a variety of chalcones that afforded the targeted compounds in very good yield compared to base catalyzed solvent free conditions as well as acid or base catalyzed refluxing conditions.
- Sultan, Aeysha,Raza, Abdul Rauf,Abbas, Muhammad,Khan, Khalid Mohammed,Tahir, Muhammad Nawaz,Saari, Nazamid
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p. 10081 - 10094
(2013/09/23)
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- Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy
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The synthesis and aromatase inhibitory activity of a new series of 2-benzylidene indanones is presented. The imidazolyl-substituted indanones displayed potent aromatase inhibitory activity. The vanilloid-based derivative 2-[4-(3-imidazol-1-ylpropoxy)-3-me
- Bansal, Ranju,Narang, Gaurav,Zimmer, Christina,Hartmann, Rolf W.
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experimental part
p. 661 - 669
(2012/05/20)
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- Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28
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Human cytomegalovirus (HCMV) is a widespread human pathogen, possessing onco-modulatory properties. Constitutive signaling of the HCMV-encoded chemokine receptor US28 and its ability to bind a broad spectrum of chemokines might facilitate HCMV-associated
- Vischer, Henry F.,Hulshof, Janneke W.,Hulscher, Saskia,Fratantoni, Silvina A.,Verheij, Mark H.P.,Victorina, Jane,Smit, Martine J.,de Esch, Iwan J.P.,Leurs, Rob
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experimental part
p. 675 - 688
(2010/04/29)
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- [4+2]cycloaddition reactions involving 2-arylmethylidene-1-thiooxoindan intermediates and antimicrobial activity evaluation of some products
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2-(4-Fluorophenyl)methylidene-1-thiooxoindane-, 2-(4-methoxyphenyl) methylidene-1-thiooxoindane-, 2-(4-N,N-dimethyaminophenyl)methylidene-1- thiooxoindane dimers 5a-c were prepared by the reaction of the corresponding , -unsaturated ketones 3a-c with Lawe
- Hegab, Mohamed I.,Elmalah, Tamer A. G.,Gad, Farouk A.
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scheme or table
p. 1665 - 1675
(2010/01/17)
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- Aldol condensation of cycloalkanones with aromatic aldehydes catalysed with TiCi3(SO3CF3)
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Efficient cross-aldol condensation of cyclopentanone, cyclohexanone and 1-indanone with various aromatic aldehydes is catalysed with TiCl3(SO3CF3) at room temperature in excellent yields.
- Iranpoor,Zeynizadeh,Aghapour
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p. 554 - 555
(2007/10/03)
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