Preparation of Argatroban Analog Thrombin Inhibitors with Reduced Basic Guanidine Moiety, and Studies of Their Cell Permeability and Antithrombotic Activities
To improve the oral absorption of thrombin inhibitors, Argatroban analogs 1, 2, 3 and 4, with reduced guanidine basicity were prepared. The in vitro thrombin inhibitory potency and their permeability of the Caco-2 cell monolayers were studied as a model f
Kim, Kyoung Soon,Moquin, Robert V.,Qian, Ligang,Morrison, Richard A.,Seiler, Steven M.,Roberts, Daniel G. M.,Ogletree, Martin L.,Youssef, Sonia,Chong, Saeho
p. 377 - 383
(2007/10/03)
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