Hydrolytic reactions of 3′-N-phosphoramidate and 3′-N-thiophosphoramidate analogs of thymidylyl-3′,5′-thymidine
The diastereomeric thiophosphoramidate analogs [(RP)- and (SP)-3′,5′-Tnp(s)T] 2 and the phosphoramidate analog [3′,5′-TnpT] 3 of thymidylyl-3′,5′-thymidine were prepared and their hydrolytic reactions over the pH-range 1-8 at 363.2 K
Ora, Mikko,Murtola, Merita,Aho, Sami,Oivanen, Mikko
p. 593 - 600
(2007/10/03)
ON THE STABILITY OF PHOSPHODIESTER-AMIDE INTERNUCLEOTIDE BOND
The stability of phosphodiester-amide internucleotide bond is compared in the deoxyribo and ribo series.The destabilizing effect of the 2'-OH group in the ribo series is discussed.
Tomasz, J.,Simoncsits, A.
p. 3905 - 3908
(2007/10/02)
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