- A new entry into 2-azabicyclo[2.1.1]hexanes via 3-(chloromethyl)cyclobutanone
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2-Azabicyclo[2.1.1]hexanes, which possess the skeleton of 2,4-methanoproline (a naturally occurring insect antifeedant), were synthesized by imination of the previously unknown 3-(chloromethyl)cyclobutanone and subsequent reductive cyclization. The precursor of the latter, 3-oxocyclobutane carboxylic acid, was prepared by two pathways in multigram quantities.
- Stevens,De Kimpe
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p. 2174 - 2178
(2007/10/03)
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