- Guanidine compound for preventing and treating chronic pain medication (by machine translation)
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The invention relates to a guanidine compound as shown in general formula (I) as a guanidine compound for preventing and treating chronic pain disease. A pharmaceutically acceptable salt thereof, a prodrug thereof, a solvate thereof, a deuterated substanc
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- BENZOFUROPYRAZOLE DERIVATIVE
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PROBLEM TO BE SOLVED: To provide a novel material having HIF inhibitory activity. SOLUTION: The present invention provides a compound represented by the following general formula (I) [where R1, R2, R3, and R4 each represent a hydrogen atom, a methoxy group, an ethoxy group, a hydroxy group, an N-morpholylurea group, or an N-(4-aminophenyl) urea group, or adjacent ones of them bind together to form an alkylenedioxy group; R5, R6, R7, R8, and R9 each represent a hydrogen atom, a methoxy group, a hydroxy group, a methoxy carbonyl group, a carboxyl group, an isopropyl group, or an isobutoxy group, or adjacent ones of them bind together to form an alkylenedioxy group]. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
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- Exploring Epidermal Growth Factor Receptor (EGFR) inhibitor features: The role of fused dioxygenated rings on the quinazoline scaffold
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A number of dioxolane, dioxane, and dioxepine quinazoline derivatives have been synthetized, and evaluated as EGFR inhibitors. Their cytotoxic activity has been tested against two cell, lines overexpressing and not expressing EGFR. Most derivatives were a
- Chilin, Adriana,Conconi, Maria Teresa,Marzaro, Giovanni,Guiotto, Adriano,Urbani, Luca,Tonus, Francesca,Parnigotto, Pierpaolo
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supporting information; experimental part
p. 1862 - 1866
(2010/08/06)
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