An efficient route to the pyrrolizidine ring system via an N-acyl anion cyclisation process
An enantioselective route to the pyrrolizidine ring system has been developed which uses an N-acyl anion cyclisation reaction as the key step. This methodology has provided the natural pyrrolizidines (-)-(1R, 8S)-1-hydroxy-pyrrolizidine 7, (-)-pyrrolizidin-1-ene-3-one 9 and (±)-trachelanthamidine 14. Extension of the process to an N-propionyl substrate provides ready access to a series of 2-methyl pyrrolizidines.
Murray, Anthony,Proctor, George R.,Murray, P. John
p. 3757 - 3766
(2007/10/03)
An asymmetric approach to the pyrrolizidine ring system via N-acetyl and N-propionyl anion cyclisation processes
An efficient route to the pyrrolizidine ring system has been developed. The method, which uses N-acetyl and N-propionyl anion cyclisation reactions as the key steps has provided the natural pyrrolizidines (-)-(1R, 8S)-1-hydroxypyrrolizidine (10), (-)-pyrrolizidin-1-ene-3-one (13), (±)-trachelanthamidine (18) together with a range of 2-methyl substituted pyrrolizidine-3-ones.
Murray,Murray, Anthony,Proctor,Proctor, George R.,Murray,Murray, P. John
p. 291 - 294
(2007/10/02)
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