- Reaction kinetic studies on the formation of N-nitrosoephedrine in vitro and in vivo
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N-Nitrosoephedrine was synthesized at a high yield (>90%). The influence of pH on the reaction process (ephedrine sulfate + nitrous acid in hydrochloric acid) was investigated and the pH-optimum determined. Furthermore the influence of coffee, ascorbic acid, citric acid, cyclamate/saccharine (10:1), smoke condensate of cigarettes, glucose and ethanol on the reaction process was also determined. The tests with animals (rats) showed that N-nitrosoephedrine could be detected in serum after the oral application of ephedrine sulfate and sodium nitrite.
- Kinawi,Schuster
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p. 219 - 225,220,221
(2007/10/05)
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