- PRODUCTION PROCESSES OF S- AND O-DIACYLATED GAMMA-GLUTAMYL-CYSTEAMINE PRODRUGS
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Methods are provided for the synthesis of a compound of formula (X). R2 is selected from -H, -C1-C4-alkyl,-C2-C4-alkenyl and C1-C4-aryl; R3 is selected from -C(O)H and
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Paragraph 0061; 0066-0067; 0074; 0078-0079
(2020/08/28)
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- PANTETHEINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGIC DISORDERS
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Compounds having the following formula (I): Formula I and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.
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Page/Page column 44
(2018/02/28)
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- Synthesis of conjugated diacetylene, metal-chelating monomers for polymerizable monolayer assemblies.
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[see structure]. Self-assembled monolayers (SAMs) of thiols on gold have been used for numerous applications. For protein targeting applications, one successful strategy is to use a metal-chelating SAM. It has also been demonstrated that polymerized SAMs
- Roy,Mallik
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p. 1877 - 1879
(2007/10/03)
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- SYNTHESE DANS LA SERIE DES PHENANTHRIDINES. IV. PREPARATION DE NOUVEAUX RADIOPROTECTEURS A MOTIF PHENANTHRIDINE
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New phenanthridines substituted in the 6-position by a β-aminoethylthiol chain have been synthesized.These new products are easily obtained from 6-methylphenanthridine by a Mannich reaction or from 6-bromophenanthridine by substitution.From the 6-carboxaldehydophenanthridine and the β-aminoethylthiol, the corresponding thiazolidine or imine are obtained.These compounds are likely to be new radioprotectors.
- Lion, Claude,Boukou-Poba, Jean-Paul,Charvy, Claude
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p. 169 - 174
(2007/10/02)
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