- Design, Synthesis, and Pharmacological Characterization of Carbazole Based Dopamine Agonists as Potential Symptomatic and Neuroprotective Therapeutic Agents for Parkinson's Disease
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We have developed a series of carbazole-derived compounds based on our hybrid D2/D3 agonist template to design multifunctional compounds for the symptomatic and disease-modifying treatment of Parkinson's disease (PD). The lead molecules (-)-11b (D-636), (-)-15a (D-653), and (-)-15c (D-656) exhibited high affinity for both D2 and D3 receptors and in GTPγS functional assay, the compounds showed potent agonist activity at both D2 and D3 receptors (EC50 (GTPγS); D2 = 48.7 nM, D3 = 0.96 nM for 11b, D2 = 0.87 nM, D3 = 0.23 nM for 15a and D2 = 2.29 nM, D3 = 0.22 nM for 15c). In an animal model of PD, the test compounds exhibited potent in vivo activity in reversing hypolocomotion in reserpinized rats with a long duration of action compared to the reference drug ropinirole. In a cellular antioxidant assay, compounds (-)-11b, (-)-15a, and (-)-15c exhibited potent activity in reducing oxidative stress induced by neurotoxin 6-hydroxydopamine (6-OHDA). Also, in a cell-based PD neuroprotection model, these lead compounds significantly increased cell survival from toxicity of 6-OHDA, thereby producing a neuroprotective effect. Additionally, compounds (-)-11b and (-)-15a inhibited aggregation and reduced toxicity of recombinant alpha synuclein protein in a cell based in vitro assay. These observations suggest that the lead carbazole-based dopamine agonists may be promising multifunctional molecules for a viable symptomatic and disease-modifying therapy of PD and should be further investigated.
- Elmabruk, Asma,Das, Banibrata,Yedlapudi, Deepthi,Xu, Liping,Antonio, Tamara,Reith, Maarten E. A.,Dutta, Aloke K.
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- Condensed-ring compound and preparation method and application thereof
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The invention discloses a condensed-ring compound and a preparation method and an application thereof. The condensed-ring compound has a structure represented by formula (I) or formula (II). The HOMOand LUMO energy levels of the fused-ring compound are completely separated, so that the energy gap width of the material is reduced, the three-wire energy level is improved, and the energy backflow from the object material to the main material is avoided to reduce the luminous efficiency; HOMO and LUMO energy levels are matched with adjacent materials, and the driving voltage is small. The devicehas large molecular structure size and good intramolecular conjugation, so it has good thermal stability, can avoid thermal decomposition of materials during film formation or use, avoids loss of material layer function, and improves luminous efficiency and luminous performance of the device. The invention also provides a preparation method of the fused-ring compound and its application as an organic electroluminescent material.
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Paragraph 0082; 0087-0091; 0388; 0390-0394
(2020/02/10)
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- Electron transporting and hole blocking organic material and application thereof in thin-film light-emitting diode
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The invention provides an electron transporting and hole blocking material with an A-D-A link structure as a core. The material is applied to a thin-film semiconductor light-emitting diode, for example, an organic light-emitting diode and a quantum dot thin-film light-emitting diode; and the molecule of the material takes bipolar carbazole and a derivative group thereof as electron donating centers, so a relatively high triplet state energy level can be maintained to ensure exciton blocking capability.
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Paragraph 0005
(2020/11/02)
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- Condensed fluorene derivative comprising heterocyclic ring
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The present invention relates to a condensed fluorene derivative comprising a heterocyclic ring and, more particularly, to an intermediate product for manufacturing a heterocyclic ring compound which can show excellent luminance and luminous efficiency when used as an organic light emitting material, while exhibiting excellent element characteristics with a long lifespan.COPYRIGHT KIPO 2020
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Paragraph 0641-0647
(2019/12/25)
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- Novel anthracene derivatives and organic light-emitting diode therewith
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The present invention relates to an anthracene derivative represented by chemical formula A, and an organic light-emitting device including the same. In the chemical formula A, R_1- R_10, L, M, and n are the same as defined in the present specification. According to the present invention, the organic light-emitting device including the compound in light-emitting layers exhibits long lifespan and high efficiency compared to existing organic light-emitting devices.COPYRIGHT KIPO 2018
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Paragraph 0319; 0412-0417
(2018/04/12)
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- Blue light emission of new anthracene derivatives produced using optimized side group link positions
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Using an anthracene chromophore as a core group and a phenyl carbazole chromophore as a side group, three new emitters of blue light, 2-DCPA, 3-DCPA and 4-DCPA, were synthesized. The three compounds differed with regard to the position of the carbazole linked to the core, with 2-DCPA and 4-DCPA using carbazole nodes and 3-DCPA using the lobe position. Density functional theory calculations were performed to determine which positions of the carbazole moiety had node characteristics and which had lobe characteristics. The PLmax values of 2-DCPA, 3-DCPA and 4-DCPA in the film state were in the blue region, at 453, 457, and 452 nm, respectively. Of these materials, 3-DCPA, i.e., that with the linkage to the lobe position, showed the highest efficiency, with a value of 2.91 cd/A, and EQE, with a value of 2.65%. In a doped device using CBP as a host material and 3-DCPA as a dopant, the ELmax emission was observed to be in the deep blue region, at 433 nm, and with a CIE value of (0.150, 0.068).
- Kang, Seokwoo,Jung, Hyocheol,Lee, Hayoon,Lee, Suji,Jung, Mina,Lee, Jaehyun,Chul Kim, Young,Park, Jongwook
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p. 369 - 378
(2018/05/09)
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- COMPOUND FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME
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This invention provides a compound for an organic electroluminescent device and an organic electroluminescent device including the same. This invention provides a compound for an organic EL device, which may have high thermal stability, improved light emission efficiency and lifetime and hole transport capability. Further, when this compound is used as a hole transport layer material in contact with a light emitting layer, thereby increasing a triplet energy, ultimately improving efficiency of the organic EL device and lifetime.
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Paragraph 277; 278; 279; 280
(2017/12/01)
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- Compound Containing Ring Linked Via Carbazole and Fluorene And Organic Electronic Element Using The Same, Terminal Thereof
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The present invention refers to carbazole ring coupled polyarylenic backbone containing organic compound and formed electrical component, its terminal number under public affairs substrate. (by machine translation)
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Paragraph 0125; 0126-0129
(2017/10/21)
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- Compound Containing Ring Linked Via Carbazole and Fluorene And Organic Electronic Element Using The Same, Terminal Thereof
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Provided in the present invention are a compound containing a ring formed by bonding carbazole and fluorine, an organic electric element using the same, and a terminal thereof. The compound of the present invention can act various roles in an organic electric element and a terminal. In addition, when being applied to an organic electric element and a terminal, the compound reduces a driving voltage of the element and increases light efficiency, service life, and stability of the element.
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Paragraph 0107-0111
(2017/12/01)
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- Organic electroluminescent element and material for organic electroluminescent elements
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An organic electroluminescence device includes: a cathode; an anode; and an organic thin-film layer having one or more layers and provided between the anode and the cathode, in which the organic layer includes an emitting layer. The emitting layer includes a first host material, a second host material and a phosphorescent dopant material. The first host material is a compound represented by a formula (1A). The second host material is a compound represented by a formula (2A).
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Page/Page column 231
(2017/08/08)
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- Condensed fluorene derivative comprising heterocyclic ring
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The present invention relates to a condensed fluorene derivative comprising a heterocyclic ring and, more particularly, to an intermediate product for manufacturing a heterocyclic ring compound which can show excellent luminance and luminous efficiency when used as an organic light emitting diode, while having excellent element characteristics with long lifespan. The heterocyclic ring compound of the present invention is represented by chemical formula A and chemical formula B.COPYRIGHT KIPO 2016
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Paragraph 0641-0647
(2016/10/08)
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- Material for organic electroluminescence device and organic electroluminescence device
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A material for organic electroluminescence device having a specific central skeleton to which a cyano-substituted aromatic hydrocarbon group or a cyano-substituted heterocyclic group is bonded at its specific position is described. Further described is an organic electroluminescence device including an organic thin film layer between an anode and a cathode. The organic thin film layer include an light emitting layer and at least one layer of the organic thin film layer contains the material for organic electroluminescence device. The material for organic electroluminescence device realizes an organic electroluminescence device with good emission efficiency.
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Page/Page column 135; 136; 157
(2016/05/02)
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- NOVEL COMPOUND FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME
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The present invention relates to a compound for an organic electroluminescent device represented by structure formula 1 or structural formula 2, and the organic electroluminescent device including the same. The present invention is able to provide the compound for an organic electroluminescent device capable of being used as hosts, hole transferring materials, and electron transferring materials, and increasing the luminous efficiency of phosphorescence light emitting materials by having excellent electrical stability and electron and hole transport ability and by exhibiting high triplet state energy; and the organic electroluminescent device.
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Paragraph 0107-0111
(2020/03/03)
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- Heterocyclic compound comprising aromatic amine group and organic light-emitting diode including the same
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The present invention relates to a heterocyclic compound comprising an aromatic amine group and an organic light emitting device including the same and, more specifically, to a heterocyclic compound, which has excellent luminance, luminance efficiency, and outstanding long lifespan characteristics when being used as an organic light emitting material. In addition, the present invention further relates to an organic light emitting device including the same.COPYRIGHT KIPO 2016
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Paragraph 0935-0940
(2016/10/07)
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- LADDER COMPOUND, AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME
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A compound represented by the following formula (1). In the formula (1), when Ar1 and Ar2 are the same substituents, as for all of the following pairs: Y1 and Y12, Y2 and Y11, Y3 and Y10, Y4 and Y9, Y5 and Y8, and Y6 and Y7, Y1 to Y12 of each pair are not the same as each other.
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Paragraph 0294-0298
(2016/11/02)
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- An electroluminescent compound and an electroluminescent device comprising the same
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The present invention relates to an organic light emitting compound applied to an organic electroluminescent device. The organic light emitting compound is represented by chemical formula 1 or chemical formula 2, and when being applied as a phosphorescent host compound in a hole transporting functional layer or a light emitting layer, provides an organic electroluminescent device having excellent driving voltage, brightness, and long lifespan.COPYRIGHT KIPO 2016
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Paragraph 0154; 0155; 0156; 0157
(2016/10/07)
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- BISCARBAZOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENCE ELEMENT USING SAME
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A biscarbazole derivative is represented by the following formula (1). A1 and A2 of the following formula (1) represent an aromatic hydrocarbon group having 6 to 30 ring carbon atoms or an aromatic heterocyclic group having 1 to 30 ring carbon atoms. However, at least one of A1 and A2 represents an aromatic heterocyclic group having 1 to 30 ring carbon atoms. Y1 to Y15 represent CR or a nitrogen atom. One of Y8 to Y11 is C (carbon atom) obtained by removing R from CR. The obtained C is bonded to L3. R each independently represents a hydrogen atom, an aromatic hydrocarbon group or the like. L1 to L3 represent a single bond or a divalent linking group. When L3 is a single bond and is bonded to Y11, L1 and L2 are divalent linking groups.
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Paragraph 0222; 0023; 00224
(2014/07/08)
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- Synthesis of 2- and 4-substituted carbazole derivatives and correlation of substitution position with photophysical properties and device performances of host materials
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A synthetic method to synthesize 4-substituted carbazole derivative was developed to study the effect of substitution position of carbazole on photophysical properties and device performances of host materials. Two high triplet energy host materials with substituents at 2- and 4-positions of carbazole were synthesized by the new synthetic approach. Substitution of electron withdrawing group at 2-position was better than the substitution at 4-position to stabilize energy levels and to improve hole transport properties. However, high glass transition temperature and high quantum efficiency were obtained in the carbazole based host material with substituent at 4-position.
- Kim, Mounggon,Lee, Jun Yeob
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- ORGANIC ELECTRONIC DEVICE, COMPOUNDS FOR SAME, AND TERMINAL
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Disclosed are an organic electronic device and a compound thereof, and a terminal.
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Page/Page column 13
(2012/02/15)
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- Enantioselective acylation of silyl ketene acetals through fluoride anion-binding catalysis
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A highly enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful α,α-disubstituted butyrolactone products. This transformation is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enantioselective thiourea anion-binding catalysis with fluoride.
- Birrell, James A.,Desrosiers, Jean-Nicolas,Jacobsen, Eric N.
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supporting information; experimental part
p. 13872 - 13875
(2011/10/09)
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