- Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class
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Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl- 2-thiazolylthio)-5-methanesulfonamido-3H-isobenzofuran-1-one 14 was found to be the optimal compound in the series wi
- Ouimet, Nathalie,Chan, Chi-Chung,Charleson, Stella,Claveau, David,Gordon, Robert,Guay, Daniel,Chun-Sing, Li,Ouellet, Marc,Percival, David M.,Riendeau, Denis,Wong, Elizabeth,Zamboni, Robert,Prasit, Petpiboon
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- CARBACEPHEM BETA-LACTAM ANTIBIOTICS
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Carbacephem β-lactam antibiotics having chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R6 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
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Page/Page column 62
(2010/11/05)
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- CARBACEPHEM β-LACTAM ANTIBIOTICS
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Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar1, Ar2, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
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Page/Page column 88
(2010/04/06)
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- Rearrangement reactions; 14: Synthesis of functionalized thiazoles via attack of heteroatom nucleophiles on allenyl isothiocyanates
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Treatment of allenyl isothiocyanates with sulfur-, oxygen-, nitrogen- or hydride-containing nucleophiles such as propane-2-thiol, thiophenol, hydrogen sulfide, alcohols, phenol or aqueous NaOH, NH3, primary or secondary aliphatic or aromatic amines, N,N,N′,N′-tetramethylguanidine or sodium cyanoborohydride resulted in ring closure to generate thiazoles bearing a functionality at position C-2 in most cases. Moreover, we report the first examples of aromatic miazole-2-phosphonates prepared by the same strategy using dialkyl or diphenyl phosphites as nucleophiles. Georg Thieme Verlag Stuttgart.
- Banert, Klaus,Al-Hourani, Baker Jawabrah,Groth, Stefan,Vrobel, Kai
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p. 2920 - 2926
(2007/10/03)
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- SYNTHESIS AND REACTIONS OF NEW VINYL ISOTHIOCYANATES
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New vinyl isothiocyanates, which can be prepared from easily accessible thiocyanates by sigmatropic shifts, show unusually high reactivity used for the synthesis of heterocyclic sulfur compounds.
- Banert, Klaus,Groth, Stefan,Hueckstaedt, Holger,Vrobel, Kai
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p. 323 - 324
(2007/10/02)
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- Alkylation, Acylation, and Carbamoylation Products of 5-Methylene-1,3-thiazolidine-2-thione
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The reaction product of prop-2-inylamine and carbon disulfide was contrary to earlier results identified as 5-methylene-1,3-thiazolidine-2-thione (3a).This was reacted with alkyl halides, acyl, carbamoyl, and thiocarbamoyl chlorides.The structures of the
- Hanefeld, Wolfgang,Bercin, Erdogan
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