- One-pot synthesis of cage alcohols
-
An efficient one-pot procedure has been developed for the synthesis of cage alcohols with hydroxy groups in the bridgehead positions. The procedure includes initial nitroxylation with nitric acid or a mixture of nitric acid with acetic acid and subsequent hydrolysis in the presence of urea.
- Klimochkin, Yu. N.,Yudashkin,Zhilkina,Ivleva,Moiseev,Oshis, Ya. F.
-
p. 971 - 976
(2017/09/07)
-
- Synthesis of hydroxy derivatives from adamantanecarboxylic acids in the system MnO2–H2SO4
-
A convenient procedure has been developed for the synthesis of mono- and dihydric cage alcohols from adamantanecarboxylic acids and their esters using the MnO2–H2SO4system. The reaction at elevated temperature involved both decarboxylation and decarbonylation of the initial acid or ester.
- Ivleva,Gavrilova,Klimochkin, Yu. N.
-
p. 785 - 790
(2016/07/30)
-
- Adamantane derivative, process for producing the same, and use thereof
-
A compound represented by general formula (1) or an innocuous salt thereof, a process for producing the same, and a schizophrenia remedy containing the same as the active ingredient (wherein the nitrogeneous ring B represents 3-azabicyclo [3.2.2] nonan-3-yl or 4-azatricyclo [4.3.1.13.8 ] undecan-4-yl; and R represents hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen). The above compound and salt have a high affinity for sigma-binding sites and are useful as an antischizophrenic drug.
- -
-
-
- SYNTHESIS OF 2,2'-(ADAMANTYLENE-1,3)-DIETHANOIC ACIDS
-
Via direct oxidative addition of 1,1-dichloroethylene to adamantane or 1,3-dimethyladamantane one obtains diethanoic acids of the adamantane series, which are useful in themselves or for preparation of other functional derivatives.Optimal reaction conditions were found by mathematical modeling.Keywords: synthesis, adamantane, dimethyladamantane, 1,1-dichloroethylene, 1,3-bis(carboxymethyl)adamantane, 1,3-bis(carboxymethyl)-5,7-dimethyladamantane, mathematical planning.
- Butenko, L. N.,Novakov, I. A.,Radchenko, S. S.,Kuznechikov, O. A.,Oglodina, T. Yu.,et al.
-
p. 1244 - 1246
(2007/10/02)
-
- Oxy-Functionalization of Adamante-1-acetic Acid and Adamantane-1-carboxylic Acid by the Ferrous Iron-Molecular Oxygen System in Aqueous Solution
-
Oxygenation reactions of adamantanes with ferrous iron-molecular oxygen in phosphate buffer were investigated and the structures of the products were elucidated.In the reaction of adamantane-1-acetic acid (1a), five oxygenated products, the C(2)-oxo, C(4)-oxo, C(2),C(6)-dioxo, C(4)-ol, and C(3)-ol derivatives, were obtained.Similar oxygenation also occurred in the reaction of adamantane-1-carboxylic acid (2a) to give three products, the C(4)-oxo, C(4)-ol, and C(3)-ol derivatives.The oxy-functionalization of 1a and 2a in 0.5M phosphate buffer (pH 6.8) was found to occur almost quantitatively on addition of an appropriate amount of ferrous iron.
- Miura, Toshiaki,Shibata, Kunihiko,Sawaya, Takuji,Kimura, Michiya
-
-