- Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin
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The preparation of three analogues of the putative diketide biosynthetic precursor (2) and eight analogues of the putative triketide biosynthetic precursor (3) of the acyl tetronic acid ionophore tetronasin, as N-acetylcysteamine thioesters (4), (5), (6), (12), (13), (14), (15), (22), (23), (24) and (25) is described. Five examples are 19F-labelled; a new, enantiospecific method for the creation of a fluorinated quarternary α-centre is presented.
- Less, Simon L.,Handa, Sandeep,Millburn, Karen,Leadlay, Peter F.,Dutton, Christopher J.,Staunton, James
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p. 3515 - 3518
(2007/10/03)
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