- In vitro inhibitory activity of boropinic acid against Helicobacter pylori
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In this study, we assessed in vitro minimum inhibitory concentration (MIC) values of some natural geranyloxycoumarins, geranyloxy- and isopentenyloxy acids against growth of Helicobacter pylori. Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 μg/mL.
- Epifano, Francesco,Menghini, Luigi,Pagiotti, Rita,Angelini, Paola,Genovese, Salvatore,Curini, Massimo
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p. 5523 - 5525
(2007/10/03)
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- Synthesis of geranyl phenyl ethers based on the cytotoxic monoterpenoids from the liverwort genus Trichocolea
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The synthesis of three geranyl ethers, methyl 4-[{(2E)-3,7-dimethyl-5- oxo-2,6-octadienyl}oxy]3-methoxybenzoate (1), methyl 4-[{(2E)-3,7- dimethyl-2,6-octadienyl}oxy]-3-methoxybenzoate (2), and methyl 4-[{(2E)- 3,7-dimethyl-2,6-octadienyl}oxy]-3-hydroxybenzoate (3), previously isolated from New Zealand Trichocolea liverworts, is described. Differing reactivity of the hydroxy groups of methyl protocatachuate toward alkylation and the ability of alkyl groups to migrate from oxygen to an ortho-oxygen in these benzene derivatives are noted.
- Baek, Seung-Hwa,Perry, Nigel B.,Weavers, Rex T.
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p. 1143 - 1145
(2007/10/03)
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