- A method for preparing prilocaine hydrochloride
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The invention relates to a synthetic process of anesthetic, in particular to a method for preparing propitocaine hydrochloride. The method includes the following steps that a, ortho-toluidine is added into dichloromethane, alpha-propionyl chloride is dropwise added at the room temperature, and the reaction lasts for 2-3 h at the temperature of 15 DEG C-25 DEG C, acid solution washing is performed on the obtained reaction liquid, then, aqueous alkali washing is performed on the obtained reaction liquid, water is added to an organic layer to separate solids out, and then propitocaine hydrochloride midbody is obtained through filtration; b, the propitocaine hydrochloride midbody obtained in the step a is added into n-propylamine, reflux is heated for 5-7 h, after the reaction is ended, concentrated hydrochloric acid is added to adjust the PH to be 1-2, white solids are separated out and are refined through ethyl alcohol of 95%, and therefore the propitocaine hydrochloride is obtained. An acetone solvent which is unfriendly to the environment and has hypotoxicity in a traditional method is replaced by the commonly used solvent dichloromethane which is basically free of toxic, and therefore environment-friendly industrial mass production becomes possible on the premise of not affecting the yield.
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Paragraph 0054
(2017/03/14)
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