- PIEZO1 AGONISTS FOR THE PROMOTION OF BONE FORMATION
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Disclosed herein are Piezo 1 agonists. Also disclosed herein are methods of stimulating tissue anabolism in a subject comprising administering an effective amount of a Piezo 1 agonist and methods for chemically mimicking mechanical stimulation of a cell expressing Piezo 1 comprising contacting a cell expressing Piezo1 with an effective amount of a Piezo 1 agonist.
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Page/Page column 30-34
(2021/04/10)
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- AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR
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A series of pyrazolopymidine derivatives, and use thereof in the preparation of a medicament for treating disease associated with FGFR and c-Met. The pyrazolopymidine derivative is a compound represented by formula (I), a tautomer, or a pharmaceutically acceptable salt thereof.
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Paragraph 0069
(2021/05/29)
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- Method of fluorination using iodonium ylides
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A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.
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Page/Page column 78; 82-83
(2019/04/30)
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- Methods for preparing 2,6-dichloro-3-fluorobenzaldehyde and fluoroquinolone compound
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The invention relates to methods for preparing 2,6-dichloro-3-fluorobenzaldehyde and a fluoroquinolone compound.2,4-dichloro-5-fluorobenzoic acid is taken as the raw material and is in reaction in a concentrated sulfuric acid solvent under the action of a bromization reagent to generate 2,4-dichloro-3-bromine-5-fluorobenzoic acid; the 2,4-dichloro-3-bromine-5-fluorobenzoic acid and Grignard reagent isopropylmagnesium chloride are in halogen-metal exchange reaction to prepare a 2,4-dichloro-3-bromine-5-fluorobenzoic acid Grignard reagent, and the 2,4-dichloro-3-bromine-5-fluorobenzoic acid Grignard reagent is further in reaction with DMF and heated for decarboxylation to obtain the target compound 2,6-dichloro-3-fluorobenzaldehyde. Compared with the prior art, the methods for preparing the 2,6-dichloro-3-fluorobenzaldehyde and the fluoroquinolone compound have the advantages that the raw materials are easy to get, the operation technology is simple, the cost is low and the like, and the methods are favorable for industrialization scale production and have larger implement values and social and economic benefits.
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Paragraph 0053; 0062
(2017/07/20)
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- FUSED BICYCLIC KINASE INHIBITORS
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Compounds of Formula (I), pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of MET, RON, ALK, IR, or IGF-1R. This Abstract is not limiting of the invention.
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- Fused Bicyclic Kinase Inhibitors
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Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.
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- FUSED BICYCLIC KINASE INHIBITORS
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Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as but not limited to tumors driven at least in part by at least one of RON, MET, IR, IGF-1 R, or ALK. This Abstract is not limiting of the invention.
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- SUBSTITUTED PYRROLO[2,3-B]-PYRIDINES AND-PYRAZINES
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Compounds of Formula I, as shown below and defined herein:(I) pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by Ron and/or Met.
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- AZAINDOLE DERIVATIVES AS KINASE INHIBITORS
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This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
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Page/Page column 94
(2010/07/02)
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- Herbicidal compositions based on 2,6-dichloro-3-fluoro-benzonitrile, and new intermediates
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The invention relates to the use of the known compound 2,6-dichloro-3-fluoro-benzonitrile as active compound in selectively-herbicidal compositions, and to new preparation processes and new intermediates for the preparation of this compound.
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