- Synthesis of aminoshikimic acid
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5-Amino-5-deoxyshikimic acid (aminoshikimic acid) was synthesized from glucose using recombinant Amycolatopsis mediterranei and also synthesized by a tandem, two-microbe route employing Bacillus pumilus and recombinant Escherichia coli.
- Guo, Jiantao,Frost
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p. 1585 - 1588
(2007/10/03)
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- Biosynthesis of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibiotics
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The biosynthetic pathway of 3-amino-5-hydroxybenzoic acid (AHBA) formation was studied with cell-free extracts from the rifamycin B producer, Amycolatopsis mediterranei S699, and the ansatrienin A producer, Streptomyces collinus Tu1892. Phosphoenolpyruvat
- Kim, Chun-Gyu,Kirschning, Andreas,Bergon, Phillipe,Zhou, Pei,Su, Esther,Sauerbrei, Bernd,Ning, Sandra,Ahn, Yonghyun,Breuer, Michael,Leistner, Eckhard,Floss, Heinz G.
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p. 7486 - 4791
(2007/10/03)
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- Synthesis and evaluation of two new inhibitors of EPSP synthase
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The enzyme EPSP synthase, EPSPS, (EC 2.5.1.19) catalyzes an unusual transfer reaction of the enolpyruvoyl moiety from phosphoenol pyruvate (2, PEP) regiospecifically to the 5-OH of shikimate 3-phosphate (1, S3P) to form 5-enol-pyruvoylshikimate 3-phosphate (3, EPSP). Two new inhibitors, (4, and 5) were prepared to probe the S3P binding site.
- Pansegrau, Paul D.,Anderson, Karen S.,Widlanski, Theodore,Ream, Joel E.,Douglas Sammons,Sikorski, James A.,Knowles, Jeremy R.
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p. 2589 - 2592
(2007/10/02)
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