- Synthesis and herbicidal activity of novel N -(2,2,2)- trifluoroethylpyrazole derivatives
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A series of novel N-(2,2,2)-trifluoroethylpyrazole derivatives were synthesized, and their structures were characterized by IR, mass spectroscopy, 1H NMR, and elementary analysis. The herbicidal activities of target compounds 10a?c and 11a?c we
- Ma, Hong-Ju,Li, Yong-Hong,Zhao, Qian-Fei,Zhang, Tao,Xie, Ru-Liang,Mei, Xiang-Dong,Ning, Jun
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- PROCESS FOR PREPARATION OF PYROXASULFONE
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The present invention discloses a process for the preparation of Pyroxasulfone of Formula (I) or salt thereof. Particularly, the present invention discloses an improved process for the preparation of hydroxycarbonimidic dibromide compound of Formula (III) or salt thereof, wherein bromine anion is recycled by using a suitable oxidizing agent. Moreover, the present invention relates to a continuous flow process for preparing of compound of Formula (I) or salt thereof.
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Page/Page column 21
(2020/12/11)
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- A two-valence sulfonyl isoxazole derivatives and use thereof
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The invention discloses a bi-titer sulfonyl isoxazole derivative in the technical field of organic compound weedicides, and application thereof. The bi-titer sulfonyl isoxazole derivative has a molecular structural formula shown as a general formula I. The invention further discloses a preparation method of the bi-titer sulfonyl isoxazole derivative. The bi-titer sulfonyl isoxazole derivative has very high activity of inhibiting weed growth and killing and removing weeds, and can be used in agricultural production, and is classified as a novel active component for weedicides.
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Paragraph 0010; 0018; 0023-0024
(2017/10/07)
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- The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds
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Target analysis of acivicin derived 3-halodihydroisoxazoles scaffolds in living non-pathogenic and pathogenic bacteria.
- Orth, Ronald,Boettcher, Thomas,Sieber, Stephan A.
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supporting information; experimental part
p. 8475 - 8477
(2011/02/24)
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- Investigation of the scope of a [3+2] cycloaddition approach to isoxazole boronic esters
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The [3+2] cycloaddition reaction of nitrile oxides and alkynylboronates provides direct access to a wide variety of isoxazole boronic esters. Specifically, this technique has been employed to generate trisubstituted isoxazole 4-boronates and disubstituted isoxazoles where the boronic ester moiety can be installed at C-4 or C-5 with high levels of regiocontrol. The application of this methodology in the synthesis of non-steroidal antiinflammatory agents is also described.
- Moore, Jane E.,Davies, Mark W.,Goodenough, Katharine M.,Wybrow, Robert A. J.,York, Mark,Johnson, Christopher N.,Harrity, Joseph P. A.
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p. 6707 - 6714
(2007/10/03)
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- Synthesis of α-Amino-3-chloro-4,5-dihydro-5-methyl-5-isoxazoleacetic Acid, a Ring-Methylated Analogue of the Antitumor Agent Acivicin (AT-125)
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α-Amino-3-chloro-4,5-dihydro-5-methyl-5-isoxazoleacetic acid (8), a ring-methylated analogue of the potent antitumor agent acivicin (AT-125), is synthesized in a 6-step procedure in 63percent overall yield from (S)-valine.Key step is the 1,3-dipolar addition of bromonitrile oxide to the N,C-protected (S)-isodehydrovaline (6) available from (S)-valine in four steps involving the photoisomerization of N-phthaloylvaline methyl ester (1).The stereochemical course of the 1,3-dipolar cycloaddition is proven by means of a X-ray structure analysis of the major diastereoisomer 7a formed in the chloronitrile oxide cycloaddition.The absolute configuration of the major (u) diastereomer 7a and the bromo derivative 7b is (αS,5R). - Key Words: Acivicin / Photochemistry / 1,3-Dipolar cycloadditions / Nitrile oxides
- Griesbeck, Axel G.,Hirt, Joachim,Peters, Karl,Peters, Eva-Maria,Schnering, Hans-Georg von
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p. 619 - 624
(2007/10/02)
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- Carboxy- and Cyano-Hydroxylation of Alkenes. - Synthesis of 3-Hydroxy-4-amino Acids and Butyrolactones via the Isoxazoline Route
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Dichloro- and dibromoformaldoximes are useful 1,3-dipolar cycloaddition reagents.They are conveniently preparated in situ, in high yields by dihalogenation of glyoxalic acid aldoxime with N-bromo- and N-chlorosuccinimide or tert-butyl hypochlorite.Dehydrohalogenation with potassium hydrogen carbonate in the presence of alkenes gives 3-halo-isoxazolines in a one-pot reaction.Reduction with iron pentacarbonyl gives β-hydroxynitriles.Methoxylation and catalytic reduction give β-hydroxy esters.Allyl alcohols and allylamines are transformed with halonitrile oxides into butyrolactones (DL-angelica lactone) and DL-3-hydroxy-4-amino acids (carnitine, 4-amino-3-hydroxybutyric acid), respectively.The lactonization is best effected by heating the γ-silyloxy ester in acetic acid with potassium hydrogen sulfate as catalyst.A synthesis of N-Boc-dihydromuscimol is described.
- Halling, Karen,Thomsen, Ib,Torssell, Kurt B. G.
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p. 985 - 990
(2007/10/02)
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- ONE POT SYNTHESIS OF 3-CHLORO-5-SUBSTITUTED IZOXAZOLES BY 1,3-DIPOLAR CYCLOADDITION
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A synthesis of 3-chloro-5-substituted isoxazoles by 1,3-dipolar cycloaddition utilizing an easy preparation of dichloroformaldoxime is reported.
- Ciarino, Dario,Napoletano, Mauro,Sala, Alberto
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p. 1171 - 1178
(2007/10/02)
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- Production of dichloroformoxime
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A method for the production of dichloroformoxime is disclosed in which chloropicrin is dissolved in a nonbasic aprotic organic solvent together with anhydrous hydrogen chloride, and said chloropicrin is reduced to dichloroformoxime in said solution in the
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