- Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines
-
In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.
- Yu, Jinhai,Zong, Weilu,Ding, Yingying,Liu, Junzhong,Chen, Lina,Zhang, Hongjuan,Jiao, Qingcai
-
p. 380 - 390
(2021/11/05)
-
- Synthesis of new chiral 2-functionalized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines
-
The asymmetric hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1,2,3,4-tetrahydroquinolines in the presence of in situ generated catalysts from [Ir(cod)Cl]2, a bisphosphine, and iodine. The enantioselectivity levels were as high as 96% ee.
- Maj, Anna M.,Suisse, Isabelle,Hardouin, Christophe,Agbossou-Niedercorn, Francine
-
p. 9322 - 9328
(2013/10/01)
-
- Studies of Tertiary Amine Oxides. LXVIII. (1). Reactions of Aromatic N-Oxides with 2-Substituted 2-Oxazolin-5-ones in the Presence of Acetic Anhydride
-
Quinoline 1-oxides 1a-f readily react with 2-phenyl- and 2-methyl-2-oxazolin-5-ones, 2a and 2b, in the presence of acetic anhydride to afford 2-substituted 4-(2-quinolyl)-2-oxazolin-5-ones 3a-h in good yields.Hydrolysis of 3a-f with 10percent hydrochloric acid under refluxing conditions gives the corresponding 2-aminomethylquinoline dihydrochlorides 5a-e or monohydrochloride 5f also in good yields.Similar results are obtained from reactions of isoquinoline 2-oxide 9 with 2a,b under the same conditions.
- Yousif, M. Mohammed,Saeki, S.,Hamana, M.
-
p. 1029 - 1034
(2007/10/02)
-