A new protecting group for aspartic acid that minimizes piperidine-catalyzed aspartimide formation in fmoc solid phase peptide synthesis
The β-3-methylpent-3-yl ester of Fmoc aspartic acid, Fmoc-Asp(OMpe)-OH, is presented as a new protecting group for aspartic acid which provides good protection against base-catalyzed aspartimide formation in Fmoc solid phase peptide synthesis. Copyright